Factor Affecting Size Reduction

Factor Affecting Size Reduction .

1. Hardness : 

Affect the Process of Size Reduction.

2. Toughness :

Fibrous material having moisture .

3. Stickiness :

4. Material Structure :

Vegetable source : cell Structure -  fibrous

5. Moisture Content :

5% - dry Grinding . 50% - wet grinding .

6. Softening temperature :

waxy substances , oils and fats .

7. Purity Required :  "wear Off"

thoroughly cleaned between batches .

8. Physiological Effect :

potent Drugs may cause problem on the operator (Enclosed mill may used .)

9. Ratio of feed size to pdt size .

we get fine powder small amt should be used .

Advantages of Size Reduction .

1. Improve drug content uniformity in the formulations .

2. increase the flow property of the powders .

3. it enances the dissolution rate absorption rate of drug which finally result into improved bioavilibility .

Disadvantages of the Size Reduction .

1. Drug degredation :  thermolabile .

2. Poor Mixing : small particle process strong cohesive force may form aggregation it will inhibit effective blending .

3. Contamiantion .